Lead Compound Analysis in Mylan v. RCT
Lead compound analysis (LCA) has been used in the evaluation of chemical compound Obviousness for the past 20 years. This approach supplemented the historic formulation of In re Dillon. While the Dillon analysis pivots about the structural similarity of the cited compound to that claimed and any motivation to make the claimed compound, LCA involves selection of a lead compound that is the most promising candidate for modification to improve its activity. As such, it represents a somewhat more difficult standard than in Dillon.